What’s the best ATS wager to make, looking at each of the 16 matchups on the NFL’s Week 16 slate? Our favorite selection against the spread is 49ers +1, but we have lots more suggestions for you, which could lead to parlay opportunities, in this article.

NFL Picks Against the Spread – Week 16

Jump to Matchup:

Pick: 49ers +1 vs. Dolphins

• Matchup: San Francisco 49ers at Miami Dolphins
• Projected Winner & Margin: 49ers by 1.5 points (Bet on this game at BetMGM)
• Spread: Dolphins -1
• Time: 4:25 p.m. ET
• Date: Dec. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Raiders -1 vs. Jaguars

• Matchup: Jacksonville Jaguars at Las Vegas Raiders
• Projected Winner & Margin: Raiders by 1.1 points (Bet on this game at BetMGM)
• Spread: Raiders -1
• Time: 4:25 p.m. ET
• Date: Dec. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos +2.5 vs. Chargers

• Matchup: Denver Broncos at Los Angeles Chargers
• Projected Winner & Margin: Broncos by 0.7 points (Bet on this game at BetMGM)
• Spread: Chargers -2.5
• Time: 8:15 p.m. ET
• Date: Dec. 19
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Chiefs -3 vs. Texans

• Matchup: Houston Texans at Kansas City Chiefs
• Projected Winner & Margin: Chiefs by 7.2 points (Bet on this game at BetMGM)
• Spread: Chiefs -3
• Time: 1 p.m. ET
• Date: Dec. 21
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings -3 vs. Seahawks

• Matchup: Minnesota Vikings at Seattle Seahawks
• Projected Winner & Margin: Vikings by 4.6 points (Bet on this game at BetMGM)
• Spread: Vikings -3
• Time: 4:05 p.m. ET
• Date: Dec. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams -3.5 vs. Jets

• Matchup: Los Angeles Rams at New York Jets
• Projected Winner & Margin: Rams by 4.3 points (Bet on this game at BetMGM)
• Spread: Rams -3.5
• Time: 1 p.m. ET
• Date: Dec. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Colts -3.5 vs. Titans

• Matchup: Tennessee Titans at Indianapolis Colts
• Projected Winner & Margin: Colts by 11.0 points (Bet on this game at BetMGM)
• Spread: Colts -3.5
• Time: 1 p.m. ET
• Date: Dec. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Eagles -3.5 vs. Commanders

• Matchup: Philadelphia Eagles at Washington Commanders
• Projected Winner & Margin: Eagles by 4.1 points (Bet on this game at BetMGM)
• Spread: Eagles -3.5
• Time: 1 p.m. ET
• Date: Dec. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cardinals -4 vs. Panthers

• Matchup: Arizona Cardinals at Carolina Panthers
• Projected Winner & Margin: Cardinals by 14.5 points (Bet on this game at BetMGM)
• Spread: Cardinals -4
• Time: 1 p.m. ET
• Date: Dec. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers -4 vs. Cowboys

• Matchup: Tampa Bay Buccaneers at Dallas Cowboys
• Projected Winner & Margin: Buccaneers by 12.5 points (Bet on this game at BetMGM)
• Spread: Buccaneers -4
• Time: 8:20 p.m. ET
• Date: Dec. 22
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Ravens -6 vs. Steelers

• Matchup: Pittsburgh Steelers at Baltimore Ravens
• Projected Winner & Margin: Ravens by 6.7 points (Bet on this game at BetMGM)
• Spread: Ravens -6
• Time: 4:30 p.m. ET
• Date: Dec. 21
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Lions -6.5 vs. Bears

• Matchup: Detroit Lions at Chicago Bears
• Projected Winner & Margin: Lions by 17.6 points (Bet on this game at BetMGM)
• Spread: Lions -6.5
• Time: 1 p.m. ET
• Date: Dec. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bengals -7.5 vs. Browns

• Matchup: Cleveland Browns at Cincinnati Bengals
• Projected Winner & Margin: Bengals by 10.6 points (Bet on this game at BetMGM)
• Spread: Bengals -7.5
• Time: 1 p.m. ET
• Date: Dec. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Falcons -8.5 vs. Giants

• Matchup: New York Giants at Atlanta Falcons
• Projected Winner & Margin: Falcons by 11.9 points (Bet on this game at BetMGM)
• Spread: Falcons -8.5
• Time: 1 p.m. ET
• Date: Dec. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers -13.5 vs. Saints

• Matchup: New Orleans Saints at Green Bay Packers
• Projected Winner & Margin: Packers by 18.1 points (Bet on this game at BetMGM)
• Spread: Packers -13.5
• Time: 8:15 p.m. ET
• Date: Dec. 23
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bills -14 vs. Patriots

• Matchup: New England Patriots at Buffalo Bills
• Projected Winner & Margin: Bills by 24.6 points (Bet on this game at BetMGM)
• Spread: Bills -14
• Time: 4:25 p.m. ET
• Date: Dec. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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