After studying the 16 matchups on the Week 18 slate in the NFL, our best against-the-spread selection is Dolphins -1. For more tips, which could lead to parlay possibilities, see below.

NFL Picks Against the Spread – Week 18

Jump to Matchup:

Pick: Dolphins -1 vs. Jets

• Matchup: Miami Dolphins at New York Jets
• Projected Winner & Margin: Dolphins by 1.6 points (Bet on this game at BetMGM)
• Spread: Dolphins -1
• Time: 4:25 p.m. ET
• Date: Jan. 5
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers +1.5 vs. Bengals

• Matchup: Cincinnati Bengals at Pittsburgh Steelers
• Projected Winner & Margin: Steelers by 5.8 points (Bet on this game at BetMGM)
• Spread: Bengals -1.5
• Time: 8 p.m. ET
• Date: Jan. 4
• TV Channel: ABC/ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Texans +1.5 vs. Titans

• Matchup: Houston Texans at Tennessee Titans
• Projected Winner & Margin: Texans by 8.2 points (Bet on this game at BetMGM)
• Spread: Titans -1.5
• Time: 1 p.m. ET
• Date: Jan. 5
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bills -2.5 vs. Patriots

• Matchup: Buffalo Bills at New England Patriots
• Projected Winner & Margin: Bills by 20.5 points (Bet on this game at BetMGM)
• Spread: Bills -2.5
• Time: 1 p.m. ET
• Date: Jan. 5
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Eagles -3 vs. Giants

• Matchup: New York Giants at Philadelphia Eagles
• Projected Winner & Margin: Eagles by 26.0 points (Bet on this game at BetMGM)
• Spread: Eagles -3
• Time: 1 p.m. ET
• Date: Jan. 5
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Lions -3 vs. Vikings

• Matchup: Minnesota Vikings at Detroit Lions
• Projected Winner & Margin: Lions by 7.6 points (Bet on this game at BetMGM)
• Spread: Lions -3
• Time: 8:20 p.m. ET
• Date: Jan. 5
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cardinals -4 vs. 49ers

• Matchup: San Francisco 49ers at Arizona Cardinals
• Projected Winner & Margin: Cardinals by 6.0 points (Bet on this game at BetMGM)
• Spread: Cardinals -4
• Time: 4:25 p.m. ET
• Date: Jan. 5
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chargers -4.5 vs. Raiders

• Matchup: Los Angeles Chargers at Las Vegas Raiders
• Projected Winner & Margin: Chargers by 8.5 points (Bet on this game at BetMGM)
• Spread: Chargers -4.5
• Time: 4:25 p.m. ET
• Date: Jan. 5
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Colts -5 vs. Jaguars

• Matchup: Jacksonville Jaguars at Indianapolis Colts
• Projected Winner & Margin: Colts by 7.8 points (Bet on this game at BetMGM)
• Spread: Colts -5
• Time: 1 p.m. ET
• Date: Jan. 5
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Commanders -6 vs. Cowboys

• Matchup: Washington Commanders at Dallas Cowboys
• Projected Winner & Margin: Commanders by 7.5 points (Bet on this game at BetMGM)
• Spread: Commanders -6
• Time: 1 p.m. ET
• Date: Jan. 5
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams +6.5 vs. Seahawks

• Matchup: Seattle Seahawks at Los Angeles Rams
• Projected Winner & Margin: Rams by 4.7 points (Bet on this game at BetMGM)
• Spread: Seahawks -6.5
• Time: 4:25 p.m. ET
• Date: Jan. 5
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Falcons -8.5 vs. Panthers

• Matchup: Carolina Panthers at Atlanta Falcons
• Projected Winner & Margin: Falcons by 16.9 points (Bet on this game at BetMGM)
• Spread: Falcons -8.5
• Time: 1 p.m. ET
• Date: Jan. 5
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Packers -10 vs. Bears

• Matchup: Chicago Bears at Green Bay Packers
• Projected Winner & Margin: Packers by 21.0 points (Bet on this game at BetMGM)
• Spread: Packers -10
• Time: 1 p.m. ET
• Date: Jan. 5
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chiefs +10.5 vs. Broncos

• Matchup: Kansas City Chiefs at Denver Broncos
• Projected Winner & Margin: Chiefs by 2.1 points (Bet on this game at BetMGM)
• Spread: Broncos -10.5
• Time: 4:25 p.m. ET
• Date: Jan. 5
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers -13.5 vs. Saints

• Matchup: New Orleans Saints at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 18.9 points (Bet on this game at BetMGM)
• Spread: Buccaneers -13.5
• Time: 1 p.m. ET
• Date: Jan. 5
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Ravens -19.5 vs. Browns

• Matchup: Cleveland Browns at Baltimore Ravens
• Projected Winner & Margin: Ravens by 26.3 points (Bet on this game at BetMGM)
• Spread: Ravens -19.5
• Time: 4:30 p.m. ET
• Date: Jan. 4
• TV Channel: ABC/ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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