Best Bets for NCAA Basketball Picks Against the Spread for Saturday, February 22
Published 8:33 pm Friday, February 21, 2025
The college basketball slate on Saturday should provide some fireworks. Our computer model has suggested picks against the spread for 10 games, including the Iowa State Cyclones taking on the Houston Cougars at Fertitta Center.
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Today’s NCAA Men’s Basketball Picks ATS
ATS Pick: Iowa State +12.5 vs. Houston
- Matchup: Iowa State Cyclones at Houston Cougars
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: Houston by 6.7 points (Bet now on BetMGM)
- Spread: Houston (-12.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Cal Baptist +9.5 vs. Grand Canyon
- Matchup: Cal Baptist Lancers at Grand Canyon Antelopes
- Time: 8 p.m. ET
- Date: February 22
- Computer Projection: Grand Canyon by 5.6 points (Bet now on BetMGM)
- Spread: Grand Canyon (-9.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Ole Miss +1.5 vs. Vanderbilt
- Matchup: Ole Miss Rebels at Vanderbilt Commodores
- Time: 3:30 p.m. ET
- Date: February 22
- Computer Projection: Ole Miss by 2.2 points (Bet now on BetMGM)
- Spread: Vanderbilt (-1.5)
- TV Channel: SEC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: Tennessee +2.5 vs. Texas A&M
- Matchup: Tennessee Volunteers at Texas A&M Aggies
- Time: 12 p.m. ET
- Date: February 22
- Computer Projection: Tennessee by 1.1 points (Bet now on BetMGM)
- Spread: Texas A&M (-2.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: TCU +7.5 vs. Cincinnati
- Matchup: TCU Horned Frogs at Cincinnati Bearcats
- Time: 12 p.m. ET
- Date: February 22
- Computer Projection: Cincinnati by 3.9 points (Bet now on BetMGM)
- Spread: Cincinnati (-7.5)
- TV Channel: ESPN2
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
Bet on this or any men’s college basketball matchup at BetMGM.
ATS Pick: Kentucky +9.5 vs. Alabama
- Matchup: Kentucky Wildcats at Alabama Crimson Tide
- Time: 6 p.m. ET
- Date: February 22
- Computer Projection: Alabama by 5.9 points (Bet now on BetMGM)
- Spread: Alabama (-9.5)
- TV Channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
ATS Pick: West Virginia +11.5 vs. Texas Tech
- Matchup: West Virginia Mountaineers at Texas Tech Red Raiders
- Time: 1 p.m. ET
- Date: February 22
- Computer Projection: Texas Tech by 8.1 points (Bet now on BetMGM)
- Spread: Texas Tech (-11.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: McNeese -10.5 vs. Texas A&M-CC
- Matchup: Texas A&M-CC Islanders at McNeese Cowboys
- Time: 5 p.m. ET
- Date: February 22
- Computer Projection: McNeese by 13.9 points (Bet now on BetMGM)
- Spread: McNeese (-10.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: UNC Greensboro -2.5 vs. Mercer
- Matchup: UNC Greensboro Spartans at Mercer Bears
- Time: 2 p.m. ET
- Date: February 22
- Computer Projection: UNC Greensboro by 5.2 points (Bet now on BetMGM)
- Spread: UNC Greensboro (-2.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
ATS Pick: Appalachian State -3.5 vs. Marshall
- Matchup: Marshall Thundering Herd at Appalachian State Mountaineers
- Time: 1 p.m. ET
- Date: February 22
- Computer Projection: Appalachian State by 6.1 points (Bet now on BetMGM)
- Spread: Appalachian State (-3.5)
- TV Channel: ESPN+
- Live Stream: Watch this game on ESPN+
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