What’s the best bet to make, looking at each of the 16 games on the NFL’s Week 3 slate? Our favorite point-spread selection is Saints -3, but we have lots more tips for you, which could lead to parlay possibilities, below.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 3 Spread Bets

Jump to Matchup:

CHI-IND | LAC-PIT | BAL-DAL | HOU-MIN | PHI-NO

Pick: Colts -1 vs. Bears

• Matchup: Chicago Bears at Indianapolis Colts
• Projected Winner & Margin: Colts by 2.8 points (Bet on this game at BetMGM)
• Spread: Colts -1
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers -1.5 vs. Chargers

• Matchup: Los Angeles Chargers at Pittsburgh Steelers
• Projected Winner & Margin: Steelers by 1.9 points (Bet on this game at BetMGM)
• Spread: Steelers -1.5
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Cowboys +1.5 vs. Ravens

• Matchup: Baltimore Ravens at Dallas Cowboys
• Projected Winner & Margin: Ravens by 0.7 points (Bet on this game at BetMGM)
• Spread: Ravens -1.5
• Time: 4:25 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings +2.5 vs. Texans

• Matchup: Houston Texans at Minnesota Vikings
• Projected Winner & Margin: Vikings by 5.1 points (Bet on this game at BetMGM)
• Spread: Texans -2.5
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Saints -3 vs. Eagles

• Matchup: Philadelphia Eagles at New Orleans Saints
• Projected Winner & Margin: Saints by 23.3 points (Bet on this game at BetMGM)
• Spread: Saints -3
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 3 Total Bets

Jump to Matchup:

Under 35.5 – Chargers vs. Steelers

• Matchup: Los Angeles Chargers at Pittsburgh Steelers
• Projected Total: 27.0 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Over 48.5 – Ravens vs. Cowboys

• Matchup: Baltimore Ravens at Dallas Cowboys
• Projected Total: 52.3 points (Bet on this game at BetMGM)
• Time: 4:25 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 49.5 – Eagles vs. Saints

• Matchup: Philadelphia Eagles at New Orleans Saints
• Projected Total: 56.5 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 46.5 – Chiefs vs. Falcons

• Matchup: Kansas City Chiefs at Atlanta Falcons
• Projected Total: 42.3 points (Bet on this game at BetMGM)
• Time: 8:20 PM ET
• Date: Sept. 22
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 41 – Panthers vs. Raiders

• Matchup: Carolina Panthers at Las Vegas Raiders
• Projected Total: 41.8 points (Bet on this game at BetMGM)
• Time: 4:05 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.