Jaguars vs. Bills Predictions & Picks: Odds, Moneyline, Spread – Monday Night Football Week 3

Published 8:38 pm Sunday, September 22, 2024

The Buffalo Bills will face the Jacksonville Jaguars at Highmark Stadium on Monday, Sept. 23 at 7:30 p.m. ET. Our computer model projects the Bills will win — see below for more information regarding the spread, over/under and final score.

Looking for NFL tickets? Head to StubHub today and see your team live.

Email newsletter signup

The Bills rank 19th in total offense (299.5 yards per game) and 13th in total defense (310.5 yards allowed per game) this year. With 295 total yards per game on offense, the Jaguars rank 21st in the NFL in 2024. Defensively, they rank 25th, surrendering 348.5 total yards per game.

BetMGM is one of the most trusted Sportsbooks in the nation. Start with as little as $1 and place your bets today.

Jaguars vs. Bills Predictions and Picks

ATS Over/Under Score Prediction
Bills (-5.5) Under (45.5) Bills 28, Jaguars 14

Ready to make your pick? Head to BetMGM using our link and start betting today.

Jaguars Betting Info

  • The moneyline for this contest implies a 33.3% chance of a victory for the Jaguars.
  • Jacksonville has covered once in two chances against the spread this year.
  • Jacksonville and its opponent have not yet hit the over in 2024.
  • Games involving the Jaguars this year have averaged 45.3 points per game, a 0.2-point differential when compared to the over/under for this contest.

Watch this game on Fubo (Regional restrictions may apply)

Bills Betting Info

  • Based on this matchup’s moneyline, the Bills have an implied win probability of 71.4%.
  • Buffalo has won one game against the spread this season.
  • The Bills have not covered the spread when favored by 5.5 points or more this season (in one opportunity).
  • Games featuring Buffalo have hit the over once this season.
  • Bills games average 47.3 total points per game this season, 1.8 more than the over/under for this matchup.

Rep your favorite NFL players with officially licensed gear. Head to Fanatics to find jerseys, shirts, hats, and much more.

Jaguars vs. Bills 2024 Scoring Insights

Pts Pts Allowed Home Pts Home Pts Allowed Away Pts Away Pts Allowed
Bills 32.5 19 34 28 31 10
Jaguars 15 19 13 18 17 20

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.